Generation of transgene-free induced pluripotent stem (iPS) cells using integrative and non-integrative approaches. 

Generation of functional cardiomyocytes from either iPS cells or by direct reprogramming of somatic cells using integrative and non-integrative approaches.

Generation of functional insulin producing β-cells from either iPS cells or by direct reprogramming of somatic cells using integrative and non-integrative approaches.

Understanding the molecular mechanisms of cell reprogramming.

Enhancing the efficiency and the kinetics of cell reprogramming.

Investigating the role of core stem cell-specific transcription factors governing stem cell self-renewal, pluripotency and differentiation.

Elucidating the epigenetic mechanisms governing stem cell self-renewal, pluripotency and differentiation.

Genome editing in pluripotent stem cells.

Understanding stem cell heterogeneity.

Identifying the crucial differences between normal stem cells vs cancer stem cells.